Pioneering Cancer Metabolism Through Nutritional Science

Advanced supplementation designed to address methionine dependence observed in cancer cells and support metabolic balance.

Over 50 years of trusted research

We are a biotech research and development organization dedicated to exploring how cancer cells use methionine and how metabolic balance can be supported. Founded on decades of pioneering research by Dr. Robert M. Hoffman, we develop methioninase-based nutritional supplements designed to help address methionine dependence observed in cancer cells.

Our mission is to advance research into fundamental cancer-cell metabolism, develop highly predictive preclinical models, and create science-backed nutritional supplements that support patients’ metabolic health.

Dr. Robert M. Hoffman

Our Approach

Methioninase: A New Class of Metabolic Therapy

Methioninase depletes methionine far more effectively than diet alone. This creates a metabolic environment where tumors become:

Slower growing
Less resistant
More responsive to standard treatments

This strategy is supported by over five decades of research led by Dr. Robert M. Hoffman and is often referred to as “The Hoffman Effect.”

Fight cancer by restricting methionine

Dr. Robert M. Hoffman

Why Methionine Matters in Cancer

What We Do

We Turn Methionine Dependence Into a Therapeutic Advantage

Cancer cells have an unusually high requirement for methionine, which is a weakness we can directly target. Our solution is methioninase, a recombinant enzyme that rapidly lowers methionine levels in the bloodstream, slowing tumor growth and making cancer cells far more responsive to treatment.

Dietary restriction alone can reduce methionine but is difficult to sustain and often insufficient. Methioninase achieves much deeper, more consistent methionine depletion, producing stronger anticancer effects across many tumor types.

By exploiting this metabolic vulnerability, we aim to enhance standard therapies, overcome resistance, and offer a new, broadly applicable enhancement in cancer treatment.

Methionine is an essential amino acid—the body cannot make it.
Healthy cells can adapt when methionine is low.
Cancer cells cannot, making methionine depletion a highly selective way to target tumors.